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As with psilocine, the relative toxicity of 4-AcO-DMT and, more specifically, neurologically, is a fortiori low: nearly no neurotoxicity. However, these are just exaggerations, and the fact is that no substantial scientific research on the subject has been carried out.

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Physical risks, including vomiting, loss of consciousness, and seizures, are especially apparent, but these are fairly rare. Nobody has died from taking it, as far as we know, nor is it likely to be physically dangerous for most individuals.

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Pregnant or breastfeeding women or those vulnerable to seizures should certainly be prevented, as with other psychedelics. Basically, heart attacks, blood pressure problems, or mental health issues, such as intense anxiety. If only to err on the side of caution, given the lack of clinical trials.

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